bsl-3 and absl-3 hvac system requirements

Containment Talk

This system creates directional airflow which draws air into the laboratory from 'clean' areas and toward 'contaminated' areas Consideration should be given to installing an HVAC control system to prevent sustained positive pressurization of the laboratory " But the 5th edi-tion of the BMBL states "A ducted air ventilation system is


Consideration should be given to installing an HVAC control system to prevent sustained positive pressurization of the animal spaces Audible alarms should be considered to notify personnel of HVAC system failure Page 6 D Laboratory Facilities (Secondary Barriers) (ABSL-3) Yes No NA 9 HEPA-filtered exhaust air from a Class II biological safety cabinet can be recirculated into the

National Institutes of Health Biosafety Level 3

Biosafety Level 3-Laboratory Certification Requirements Introduction Biosafety Level 3 (BSL-3/ABSL-3) containment laboratories for animals and research are the most difficult containment level facilities to design and operate They should be certified for use before initial operation and subsequently on an annual schedule or after a program change renovation or replacement of critical HVAC

Assessment Tool for Key Processes associated with the

ABSL-3 Animal Biosafety Laboratory ACDP Advisory Committee on Dangerous Pathogens BMBL Biosafety in Microbiological and Biomedical Laboratories BSCII Biological Safety Cabinet – Class II BSL-3 Biological Safety Level 3 CDC Center for Disease Control CCTV Closed Circuit Television EDP Emerging Dangerous Pathogen EDPL Emerging Dangerous Pathogen Laboratory EDPLN Emerging

Click to edit Master title style HVAC Systems for BSL‐3

2 BSL‐3 HVAC System Performance Criteria 3 Additional Performance Enhancements Click to edit Master title style 9/18/20199/17/2019 3 Document the requirements: •Airflow reversals must: •Be well‐defined •Meet the risk assessment •Be achievable •Be coupled with SOPs Coupling air reversal infrastructure with SOPs avoids excessive facility costs and operational complexities

Federal Select Agent Program

Policy Statement BSL-3/ABSL-3 HVAC Verification: Initial HVAC design verification must be performed and documented by someone with experience and expertise with the HVAC system prior to operation This initial HVAC design verification ensures that secondary containment is maintained under failure conditions to prevent possible exposure of personnel outside the containment boundary After HVAC

OHSU Engineering Standards Marquam REV 0 docx

Biosafety Level 3 (BSL-3/ABSL-3) containment laboratories for animals and research are the most difficult containment level facilities to design and operate They should be certified for use before initial operation and subsequently on an annual schedule or after a program change renovation or replacement of critical HVAC/exhaust system components (specifically fans air valves or fan motors


i 23 00 00 – General Mechanical Requirements (HVAC) ii 23 09 23 – Building Automation Temperature Control System (BAS) B UGA Exhaust HEPA Design Criteria i All BSL-3/ABSL-3 laboratories at UGA require HEPA filters to be placed on their exhaust This section provides a reference diagram and detailed requirements

Index [

– facility requirements 16–18 heating ventilation and air-conditioning (HVAC) system 80 82 high-efficiency particulate air (HEPA) filters 23 31 32 34–35 37 82 89 high-pressure water cleaning 64 i incident and emergency response planning 117–118 – biosecurity and biosafety 118 incinerators 35 infectious substances shipping and

IV Validacin de Procesos

Design Requirements Manual Issuance Notice 12/12/2016 (Revision 1 0: 02/13/2018)* *The Design Requirements Manual is a living document and will be maintained and updated on a regular basis The contents of this work are subject to change through both periodic development cycles as well as when revisions are determined necessary by the Division of Technical Resources

Science Safety Security newsletter

any BSL-3/ ABSL-3 facility ANSI/ASSE Z9 14 cont from pg 1 and the labora-tory activity for the 1 300+ BSL-3/ABSL-3 laboratories that exist in the United States (American Biological Safety Association 2008) The ventilation system of a BSL-3/ABSL-3 labora-tory is central to its performance and operation It is speciically


BSL-3 and ABSL-3 HVAC System Requirements - Part I VAC systems play acritical role in control of hazards in a bio-containment facility aboratories (BSL)-3 and Biosafety L Animal Biosafety Laboratories (ABSL)-3 animal facilities shall comply with all requirements for BSL-2 laboratories and ABSL-2 animal facilities as described in the DRM Chapter 6 Mechanical Systems Design This article

Product Results

ANSI/ASSE Z9 14-2014 Testing and Performance-Verification Methodologies for Vent Systems for BSL-3 and ABSL-3 Facilities ANSI/ASSP Z10-2019 Occupational Health and Safety Management Systems Additive Manufacturing/3D Printing Bundle (AIHce EXP 2018 OnDemand) Aerosols in Various Environments (AIHce EXP 2019 OnDemand)


The most complex component of a BSL-3 Laboratory is the mechanical suite which includes the HVAC and air filtration/pressure controls Many parts of the world do not have the mechanical trades necessary to build these complex systems Germfree has a complete in house engineering team specializing in the unique requirements of BSL-3 Laboratories

American Society of Safety Engineers (ASSE)

home products services datasheets standards and technical documents american society of safety engineers (asse) testing and performance-verification methodologies for ventilation systems for biosafety level 3 (bsl-3) and animal biosafety level 3 (absl-3) facilities -- ansi/asse z9 14-2014

We have the solution to transform

BSL-3/ABSL-3 (inc Luding Ag SeLect Agent enhAnced And BSL-4/ABSL-4 ReSeARch) yellow = HvAc supply : conditioned And Question ABle Air redirected outside tHe enclosure for filtrAtion By bB power units ArcHitecturAlly renovAted positive pressure cleAn environment bioBUBBLE power unit vinyl wAll bioBUBBLE custom soft duct system 6 cleAn rooM isolAtion bArrier enclosures

US Laboratory Cleanroom Design Fundamentals

BSL-3 plus: •Separate building or isolated zone Dedicated supply and exhaust vacuum and decon systems Other requirements outlined in the text Primary barriers = All procedures conducted in Class III BSCs or Class I or II BSCs in combination with full-body air-supplied positive pressure personnel suit BSL-3 practices plus: Clothing change before entering Shower on exit All material

Designing HVAC systems for biosafety level requirements

By Joseph DeLaurentis Kinetics Biopharm The design of HVAC systems to meet biosafety level requirements presents special challenges The design must be closely studied and evaluated for safety capital and operating cost maintenance accessibility construction and validation schedule goals as well as any additional client requirements

Mike Connor PE

The first floor contains Animal Biosafety Level 3 (ABSL-3) animal housing toxicology labs necropsy and related support spaces The second level of the two-story structure consists of shell space for future Biosafety Level 3 (BSL-3) research laboratories and a vaccine development facility Talka Connor's original association with the building began in 1998 when we were hired to design

Animal Biosafety Levels

ABSL-4 builds upon the standard practices procedures containment equipment and facility requirements of ABSL-3 However ABSL-4 cabinet and suit laboratories have special engineering and design features to prevent microorganisms from being disseminated into the environment and personnel The ABSL-4 cabinet laboratory is distinctly different from an ABSL-3 laboratory containing a Class III

Appendix D—Agriculture Pathogen Biosafety

Using the containment features of the standard ABSL-3 facility as a starting point BSL-3-Ag facilities are specifically designed to protect the environment by including almost all of the features ordinarily used for BSL-4 facilities as enhancements All BSL-3-Ag containment spaces must be designed constructed and certified as primary containment barriers 344 Biosafety in Microbiological and

Lovelace Respiratory Research Institute Commissions

Lovelace Respiratory Research Institute (LRRI) a private biomedical research organization in Albuquerque N M recently opened an advanced 9 500-sf ABSL-3 aerobiology laboratory after an intensive commissioning and validation process The facility is used to study aerosolized pathogens on the CDC's Select Agent List and for vaccine efficacy testing

Time Off for Vacation Sick and Personal Needs

Laboratory re-commissioning - ABSL-3 and BSL-3 checklist Building _____ Room No _____ Investigator _____ 1 Laboratory furniture is capable of supporting anticipated loading and uses Yes No 2 For each BSC a test certificate is available to indicate that the cabinet has passed certification requirements in accordance with NSF 49

2 03 BSL3 Design Guidelines Introduction and Basis of Design

specialized requirements for BSL-3 and ABSL-3 environments These Guidelines were developed specifically for the requirements of high containment facilities for both laboratory and animal facilities These Guidelines are based on input from several sources including the following: Biosafety in Microbiological and Biomedical Laboratories 5th Edition NIH Design Requirements Manual (DRM)

Dugway Proving Ground

This project required World BioHazTec to provide Subject Matter Expertise to design construct commission and certify a complex BSL-3 facility that meets rigorous containment requirements Big-D Construction was the prime contractor for the design construction commissioning and certification for a BSL-2/BSL-3 convertible laboratory called the Life Science Test Facility (LSTF) designed with

University of Louisville – Council Rock Consulting

HVAC and exhaust systems failure responses were tested The emergency power system was tested under load conditions and effects on the ventilation system will be recorded Noise levels were evaluated Since building occupancy CRC has commissioned/certified the BSL-3 ABSL-3 and vivarium laboratories annually

nih bsl 3 ante room

National Institutes of Health Biosafety Level 3-Laboratory Certification Requirements Example: BSL-3 Laboratory corridor Viral isolation - 0 05 -0 05 - 0 05 Air lock/anteroom ** Figure Provided For Illustration Purposes Only ** 5 Develop HVAC system and electrical systems failure tests consistent with laboratory design parameters

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