photothermally targeted thermosensitive polymer

Key Targeting Approaches for Pharmaceutical Drug

Drug targeting is defined as the ability of a drug molecule to accumulate in the target organ or tissue selectively such that the concentration of the drug at the disease site is high while its concentration in nontarget organs and tissues is low preferably below certain minimal level so as to prevent any toxic effect Thus drug targeting can overcome the non-specific toxic effect of

Thermostability of Biological Systems: Fundamentals

Fig (5) An illustration (not to scale) of some important structures/confirmations of a typical biological tissue (A) mammalian cell (B) cell plasma membrane (C) and protein (D): A biological tissue typically consists of cells (1) extracellular matrix (2) and blood vessels (3) through which oxygen and nutrients are transported to the cells a mammalian cell consists of many important sub


To develop a near-infrared (NIR) light-sensitive liposome which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX) and evaluate their potential utility for enhancing antitumor activity and controlling drug release The liposomes (DOXHAuNS-TSL) were designed based on a thermal sensitive liposome (TSL) formulation and hydrophobically modified HAuNS were attached onto the membrane

Mechanisms of light‐induced liposome permeabilization

Thermosensitive liposomes (TSL) can be activated with photothermal transducers and NIR light is an appealing wavelength for clinical use due to its deeper tissue penetrance Kwon et al developed a TSL system tethering gold clusters on liposome bilayers with NIR sensitivity 73 Light absorbed by the gold cluster is converted into heat and transferred to the TSL causing membrane destabilization


The study of carbon-based nanomaterials (CBNs) for biomedical applications has attracted great attention due to their unique chemical and physical properties including thermal mechanical electrical optical and structural diversity With the help of these intrinsic properties CBNs including carbon nanotubes (CNT) graphene oxide (GO) and graphene quantum dots (GQDs) have been extensively

ACS Applied Materials Interfaces Journal Impact 2019

Journal Impact 2019-20 | Factor Prediction Ranking ACS Applied Materials Interfaces Journal Impact 2019-20 is 8 330 39% scientists predict ACS Applied Materials Interfaces Journal Impact 2019-20 will be in the range of 9 0 ~ 9 5 ACS Applied Materials Interfaces

Thermosensitive Micelles Based on Folate

Read Thermosensitive Micelles Based on Folate‐Conjugated Poly( N ‐vinylcaprolactam) ‐block‐ Poly(ethylene glycol) for Tumor‐Targeted Drug Delivery Macromolecular Bioscience on DeepDyve the largest online rental service for scholarly research with thousands of

STONE DISEASE Preventing Migration of Stones during

The polymer was easily removed from the ureter by infusing cold water Conclusion: The use of this thermosensitive polymer proximal to ureteral stones prevents migration and is not traumatic to the ureter Editorial Comment The authors describe the use of a novel thermosensitive polymer to stabilize calculi during endourological procedures

Stork: An injectable thermosensitive photothermal

The conjugated-polymer backbones can directly convert incident light into heat endowing the PNT-gel with high photothermal conversion efficiency (η = 52 6%) and enhanced photothermal stability Meanwhile the mild host-guest assembly enable the shear-thinning injectability photothermally-driven and reversible gel-sol conversion of the hydrogel

Optically responsive delivery platforms: from the design

Photothermally responsive drug carriers are able to adsorb light energy and convert it into heat micelle- liposome- and polymer-based materials modified with light-responsive parts can be fabricated The targeted delivery did not cause systemic toxicity after injection

International Year of the Periodic Table: Precious metals

About this collection Guest Edited by Zhiqun Lin Journal of Materials Chemistry A Associate Editor Georgia Institute of Technology USA and Xiaogang Qu Journal of Materials Chemistry B Associate Editor Changchun Institute of Applied Chemistry Chinese Academy of Sciences China This themed collection is the fourth in a series celebrating the International Year of the Periodic Table

US Patent Application for Environmentally Responsive

A method for mechanical stimulation of cells includes providing a substrate comprising a plurality of microactuators embedded in an environmentally responsive hydrogel polymer layer disposed on a region of the surface adhering at least one cell to the substrate and exposing the environmentally responsive hydrogel polymer layer to a stimulus the stimulus changing a volume of the

Mechanics from Calorimetry: A New Probe of Elasticity for

Temperature-sensitive hydrogels based on polymers such as poly(N-isopropylacrylamide) (PNIPAM) undergo a volume phase transition in response to changes in temperature During this transition distinct changes in both thermal and mechanical properties are observed Here we illustrate and exploit the inherent thermodynamic link between thermal and mechanical properties by showing that the

MICROGELS Old Materials with New Applications _

HYBRID MICROGELS FOR DRUG DELIVERY Photothermally modulated volume transitions in polymer microgels have promising applications in drug delivery To induce photothermal transitions typically photosensitive moieties (dyes or metal nanoparticles) (92–98) are embedded in microgels and irradiated at their resonance wavelengths

Multifunctional nanoplatforms for subcellular delivery of

Barhoumi et al developed a photothermally targeted thermosensitive polymer-masked NPs based on poly(N-isopropylacrylamide)-co-polyacrylamide copolymer By conjugating this copolymer to the silica core-gold shell NPs the peptide ligand decorated on the NPs surface can be


Multi-step precipitation separation system was developed by using aqueous mixtures of some thermosensitive polymers The following three polymers were used here poly(N-n-propylacrylamide) poly(N of the non-targeted polymers due to their phase transitions but also by their non-specific entanglement with the targeted polymers


THERMOSENSITIVE POLYMERS AS SMART MATERIALS The change of thermosensitive polymer physical state occurs at the LCST and depends on the can be proposed depending of customer wishes (targeted structures quantities) SP CATALOG SP DESCRIPTION SP PUBLICATIONS ZAC Via Domitia

Multifunctional nanoparticles

A major aim of medicine has long been the early and accurate diagnosis of clinical conditions providing an efficient treatment without secondary effects With the emergence of nanotechnology the achievement of this goal seems closer than ever To this end the development of novel materials and devices operating at the nanoscale range such as nanoparticles provides new and powerful tools

Gelation of liposome interior A novel method for drug

Gelation of liposome interior A novel method for drug encapsulation D D Lasic Xiangliang Yang Huibi Xu Doxorubicin-induced co-assembling nanomedicines with temperature-sensitive acidic polymer and their in-situ -forming hydrogels for Carrier-Mediated and Targeted Cancer Drug Delivery Oxidative Stress in Cancer

Supramolecular Structures and Self

Supramolecular Structures and Self-Association Processes in Polymer biodistribution of the drugs towards targeted delivery into tissue of interest and allow triggered release of the active cargo In this thermosensitive polymers where the phase separation is achieved by

A multifunctional platform with single

Infectious diseases caused by multidrug-resistant (MDR) bacteria especially MDR Gram-negative strains have become a global public health challenge Multifunctional nanomaterials for controlling MDR bacterial infections via eradication of planktonic bacteria and their biofilms are of great interest In this study we developed a multifunctional platform (TG-NO-B) with single NIR laser


2015 05: Sang Hee Ahn Moon Soo Gil Doo Sung Lee Youngyih Han Hee Chul Park Jason W Sohn Hye Yeong kim Eun Hyuk Shin Jeong Il Yu Jae Myoung Noh Jun Sang Cho Sung Hwan Ahn and Doo Ho Choi Preclinical investigation for developing injectable fiducial markers using a mixture of BaSO4 and biodegradable polymer for proton therapy Medical Physics 2015 42(5) 2626-2637


Cell-assisted synthesis of conducting polymer - polypyrrole - for the improvement of electric charge transfer through fungal cell wall March 01 2019 [ MEDLINE Abstract] Regulation of osteoblast differentiation by osteocytes cultured on sclerostin antibody conjugated TiO2 nanotube array March 01 2019 [ MEDLINE Abstract]

Functional Thin Films Lab (FTFL)

Jieung Baek† Younghak Cho† Hyun-Ji Park† Goro Choi Jong Seung Lee Minseok Lee Seung Jung Yu Seung-Woo Cho* Eunjung Lee* and Sung Gap Im* A Surface- Tailoring Method for Rapid Non-thermosensitive Cell Sheet Engineering via Functional Polymer Coatings Advanced Materials 2020 32(16) 1907225 DOI: 10 1002/adma 201907225

Effect of Molecular Structure of Side Chain Polymers on

Polymers on Click Synthesis of Thermosensitive Molecular Brushes Christie Maggie Lau Christie Maggie Effect of Molecular Structure of Side Chain Polymers on Click Synthesis of Thermosensitive Molecular Brushes (2017) in understanding their structure-property relationships so that they can be targeted for different purposes

Efficacy of an Injectable Thermosensitive Gel on

Purpose For easy application to targeted area or in laparoscopic surgery proper injectable antiadhesive agents are needed The efficacy of two injectable antiadhesive agents- the thermosensitive poly (organophosphazene) hydrogel (Gel group) and a mixed solution of hyaluronate and carboxymethyl cellulose (Guardix-sol Hanmi Medicare Korea Gd group) were compared with that of a positive

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